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Towards FAIR nanosafety data

Nature Nanotechnology volume 16, pages 644–654 (2021)Cite this article

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Matters Arising to this article was published on 23 December 2021

Abstract

Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have investigated environmental and health safety aspects of nanomaterials, but the reuse of accumulated data is clearly lagging behind. Here we summarize challenges and provide recommendations for the efficient reuse of nanosafety data, in line with the recently established FAIR (findable, accessible, interoperable and reusable) guiding principles. We describe the FAIR-aligned Nanosafety Data Interface, with an aggregated findability, accessibility and interoperability across physicochemical, bio–nano interaction, human toxicity, omics, ecotoxicological and exposure data. Overall, we illustrate a much-needed path towards standards for the optimized use of existing data, which avoids duplication of efforts, and provides a multitude of options to promote safe and sustainable nanotechnology.

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Fig. 1: Accessible nanosafety data.
Fig. 2: Interoperable nanosafety data.
Fig. 3: Reusable nanosafety data.

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Data availability

The datasets described here are available through the Nanosafety Data Interface and the NanoReg2 database (https://search.data.enanomapper.net/projects/nanoreg2). Data generated within NANoREG, NanoReg2 and the omics metadata are publicly available under CC BY-NC-SA 4.0 license. The NanoReg2 generated data is also available as SQL (DOI: 10.5281/zenodo.4713745, accessed 23 April 2021). Data that originate from the projects NanoTEST, ENPRA, MARINA and NANOGENOTOX are currently restricted from public use.

Code availability

The eNanoMapper data model is implemented in the open-source chemical substance management software AMBIT (http://ambit.sf.net). Machine readability for data retrieval and analysis is facilitated via an open source JavaScript client library (https://github.com/ideaconsult/jToxKit) and a Python client library (https://github.com/ideaconsult/pynanomapper).

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Acknowledgements

The work leading to this article has received funding from the European Union’s Horizon 2020 Research and Innovation programme, Grant Agreements no. 646221 (NanoReg2, 2015–2019), no. 814401 (Gov4Nano, 2019–2022) and no. 814425 (RiskGONE 2019–2023). In addition, the European Union’s 7th Framework Programme projects NANoREG (2013–2017, Grant Agreement no. 310584), NanoTEST (2008–2012, no. 201335) and ENPRA (2009–2012, no. 228789), the European Union’s Health Programme Joint Action project NANOGENOTOX (2010–2013, no. 2009 21 01) and the US NIH NCI caNanoLab portal are acknowledged for providing data.

Author information

Authors and Affiliations

  1. Ideaconsult Ltd, Sofia, Bulgaria

    Nina Jeliazkova, Vedrin Jeliazkov, Nikolay Kochev & Vesselina Paskaleva

  2. Medical and Biological Research Laboratory, Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria

    Margarita D. Apostolova

  3. Istituto Superiore di Sanità, Rome, Italy

    Cristina Andreoli, Flavia Barone, Chiara Battistelli, Cecilia Bossa & Isabella De Angelis

  4. Mer Molécules Santé, Université Catholique de l’Ouest, Angers, France

    Andrew Barrick & Amélie Châtel

  5. Institute of Physical Chemistry ‘Ilie Murgulescu’ of the Romanian Academy, Bucharest, Romania

    Alina Botea-Petcu, Daniela Gheorghe, Aurica Precupas, Romica Sandu & Speranta Tanasescu

  6. Department of Environmental Chemistry, Health Effects Laboratory, Norwegian Institute for Air Research, Kjeller, Norway

    Maria Dusinska, Naouale El Yamani, Espen Mariussen & Elise Rundén-Pran

  7. Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany

    Anna Giusti & Andrea Haase

  8. GAIKER Technology Centre, Basque Research and Technology Alliance, Zamudio, Spain

    Paloma Gómez-Fernández & Isabel Rodríguez Llopis

  9. Department of Toxicology, Misvik Biology, Turku, Finland

    Roland Grafström, Pekka Kohonen & Penny Nymark

  10. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Roland Grafström, Pekka Kohonen & Penny Nymark

  11. Group of Environmental Chemometrics, Faculty of Chemistry, University of Gdansk, Gdańsk, Poland

    Maciej Gromelski & Tomasz Puzyn

  12. QSAR Lab Ltd, Gdańsk, Poland

    Maciej Gromelski & Tomasz Puzyn

  13. National Research Centre for the Working Environment, Copenhagen, Denmark

    Nicklas Raun Jacobsen & Keld Alstrup Jensen

  14. Faculty of Chemistry, Department of Analytical Chemistry and Computer Chemistry, University of Plovdiv, Plovdiv, Bulgaria

    Nikolay Kochev & Vesselina Paskaleva

  15. Expertise and Assays in Ecotoxicology Unit, French National Institute for Industrial Environment and Risks, Verneuil-en-Halatte, France

    Nicolas Manier

  16. Joint Research Centre, European Commission, Ispra, Italy

    Agnieszka Mech & Kirsten Rasmussen

  17. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain

    José María Navas

  18. Institute of Occupational Medicine, Edinburgh, UK

    Peter Ritchie

  19. Netherlands Organisation for Applied Scientific Research (TNO), Utrecht, Netherlands

    Neeraj Shandilya

Authors
  1. Nina Jeliazkova
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  2. Margarita D. Apostolova
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  3. Cristina Andreoli
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  4. Flavia Barone
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  5. Andrew Barrick
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  6. Chiara Battistelli
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  7. Cecilia Bossa
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  36. Speranta Tanasescu
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  38. Penny Nymark
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Contributions

N.J. and P.N. conceptualized the study, interpreted the results and drafted the manuscript. A.H. designed and coordinated the work and acquisition of the data. M.D.A., C.A., F.B., A.B., C. Battistelli, C. Bossa, A.B.-P., A.C., I.D.A., M.D., N.E.Y., A.G., P.G.-F., D.G., R.G., M.G., N.R.J., V.J., K.A.J., N.K., P.K., N.M., E.M., A.M., J.M.N., V.P., A.P., T.P., K.R., P.R., I.R.L., E.R.-P., R.S., N.S. and S.T. contributed to the acquisition and analysis of data, as well as the formulation of the methods and results. All the authors approved the final version of the manuscript and agree to being accountable for their own contributions.

Corresponding authors

Correspondence to Nina Jeliazkova or Penny Nymark.

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The authors declare no competing interests.

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Peer review information Nature Nanotechnology thanks Wojciech Chrzanowski and Iseult Lynch for their contribution to the peer review of this work.

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Supplementary information

Supplementary information

Supplementary Figs. 1 and 2, Methods and Tables 1 and 2.

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Jeliazkova, N., Apostolova, M.D., Andreoli, C. et al. Towards FAIR nanosafety data. Nat. Nanotechnol. 16, 644–654 (2021). https://doi.org/10.1038/s41565-021-00911-6

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