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Targeting immune cells within lymph nodes

Increased delivery to immune cells in the cortex and paracortex of the lymph node can be achieved by conjugating cargo to nanoparticles via linkers that release at programmable rates.

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Fig. 1: Two-stage delivery to lymph-node-resident immune cells.


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Correspondence to Christopher J. H. Porter or Natalie L. Trevaskis.

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The authors are inventors of an oral lymph targeting technology platform licenced from Monash University to PureTech Health.

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Porter, C.J.H., Trevaskis, N.L. Targeting immune cells within lymph nodes. Nat. Nanotechnol. 15, 423–425 (2020).

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