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Cancer nanotechnology

Transcellular transfer of nanomedicine

Nature Nanotechnology volume 14, pages 731–732 (2019)Cite this article

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Nanoparticles designed to harness transcytosis achieve deeper tumour penetration.

Increasing the delivery and penetration of drugs into tumours is the holy grail in the treatment of cancer1 and has emerged as a major goal in cancer nanomedicine research. Once injected into the bloodstream, nanoparticles need to extravasate through the leaky gaps in the endothelial barrier into the tumour, where they then face stromal barriers2. Heterogeneity in vascular leakiness and stromal barriers can become a bottleneck in the efficacy of nanoparticles2. These biological barriers could be circumvented if a nanoparticle was able to simply transfer through the cells.

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Fig. 1: Transcytosis of nanomedicine across cellular barrier.

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Authors and Affiliations

  1. Center for Engineered Therapeutics, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Hae Lin Jang & Shiladitya Sengupta

  2. Division of Health Sciences and Technology, Harvard–Massachusetts Institute of Technology, Massachusetts Institute of Technology, Boston, MA, USA

    Hae Lin Jang & Shiladitya Sengupta

  3. Dana Farber Cancer Institute, Boston, MA, USA

    Shiladitya Sengupta

Authors
  1. Hae Lin Jang
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  2. Shiladitya Sengupta
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Correspondence to Hae Lin Jang or Shiladitya Sengupta.

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Jang, H.L., Sengupta, S. Transcellular transfer of nanomedicine. Nat. Nanotechnol. 14, 731–732 (2019). https://doi.org/10.1038/s41565-019-0494-y

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