Review Article | Published:

Interfacing nature’s catalytic machinery with synthetic materials for semi-artificial photosynthesis

Nature Nanotechnologyvolume 13pages890899 (2018) | Download Citation

Abstract

Semi-artificial photosynthetic systems aim to overcome the limitations of natural and artificial photosynthesis while providing an opportunity to investigate their respective functionality. The progress and studies of these hybrid systems is the focus of this forward-looking perspective. In this Review, we discuss how enzymes have been interfaced with synthetic materials and employed for semi-artificial fuel production. In parallel, we examine how more complex living cellular systems can be recruited for in vivo fuel and chemical production in an approach where inorganic nanostructures are hybridized with photosynthetic and non-photosynthetic microorganisms. Side-by-side comparisons reveal strengths and limitations of enzyme- and microorganism-based hybrid systems, and how lessons extracted from studying enzyme hybrids can be applied to investigations of microorganism-hybrid devices. We conclude by putting semi-artificial photosynthesis in the context of its own ambitions and discuss how it can help address the grand challenges facing artificial systems for the efficient generation of solar fuels and chemicals.

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Acknowledgements

N.K. gratefully acknowledges a Royal Society Newton International Fellowship (NF160054). K.K.S. acknowledges the Harvard University Center for the Environment Fellowship. This work was supported by Director, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences and Biosciences Division, of the US Department of Energy under Contract No. DE-AC02-05CH11231, FWP No. CH030201 (Catalysis Research Program). E.R. and J.Z.Z. acknowledge an ERC Consolidator Grant ‘MatEnSAP’ (682833). We thank N. Heidary, W. Robinson and S. Kalathil for discussions.

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Affiliations

  1. Department of Chemistry, University of Cambridge, Cambridge, UK

    • Nikolay Kornienko
    • , Jenny Z. Zhang
    •  & Erwin Reisner
  2. Department of Chemistry, University of California, Berkeley, CA, USA

    • Nikolay Kornienko
    • , Kelsey K. Sakimoto
    •  & Peidong Yang
  3. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA

    • Kelsey K. Sakimoto
  4. Department of Systems Biology, Harvard Medical School, Boston, MA, USA

    • Kelsey K. Sakimoto
  5. Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    • Peidong Yang
  6. Kavli Energy NanoSciences Institute, Berkeley, CA, USA

    • Peidong Yang
  7. Department of Materials Science and Engineering, University of California, Berkeley, CA, USA

    • Peidong Yang

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  5. Search for Erwin Reisner in:

Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Peidong Yang or Erwin Reisner.

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/s41565-018-0251-7

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