CANCER NANOMEDICINE

A synthetic lethal bullet

Nanoparticles loaded with paclitaxel and nintedanib induce synthetic lethality in endometrial cancer cells.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: TPGS–PLGA nanoparticles loaded with nintedanib and paclitaxel extravasate through the leaky tumour vasculature and reach tumour cells.

References

  1. 1.

    Ebeid, K. et al. Nat. Nanotech. https://doi.org/10.1038/s41565-017-0009-7 (2017).

  2. 2.

    Kreuter, J. in Encyclopedia of Pharmaceutical Technology (eds Swarbrick, J. & Boylan, J. C.) 165–190 (Dekker, New York, 1994).

  3. 3.

    Gottesman, M. M., Fojo, T. & Bates, S. E. Nat. Rev. Cancer 2, 48–58 (2002).

    Article  Google Scholar 

  4. 4.

    du Bois, A. et al. Lancet Oncol. 17, 78–89 (2016).

    Article  Google Scholar 

  5. 5.

    Reck, M. et al. Lancet Oncol. 15, 143–155 (2014).

    Article  Google Scholar 

  6. 6.

    O’Neil, N. J., Bailey, M. L. & Hieter, P. Nat. Rev. Genet. 18, 613–623 (2017).

    Article  Google Scholar 

  7. 7.

    Jamal-Hanjani, M. et al. N. Engl. J. Med. 376, 2109–2121 (2017).

    Article  Google Scholar 

  8. 8.

    Strebhardt, K. & Ullrich, A. Nat. Rev. Cancer 8, 473–480 (2008).

    Article  Google Scholar 

  9. 9.

    Bridges, C. B. Amer. Nat. 56, 51–63 (1922).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Christian Rolfo or Elisa Giovannetti.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rolfo, C., Giovannetti, E. A synthetic lethal bullet. Nature Nanotech 13, 6–7 (2018). https://doi.org/10.1038/s41565-017-0038-2

Download citation

Further reading

Search

Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research