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Fungal pathogenesis

Metabolic sensing tips the balance of drug tolerance in fungal meningitis

Sensing of brain glucose by the fungal pathogen Cryptococcus neoformans alters lipid metabolism and membrane composition in the fungus, rendering it drug tolerant.

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Fig. 1: Glucose sensing alters Cryptococcus membrane composition leading to AmB tolerance.


  1. Brown, G. D. et al. Sci. Transl. Med. 4, 165rv13 (2012).

    Article  PubMed  Google Scholar 

  2. Chen, L. et al. Nat. Microbiol. (2024).

    Article  PubMed  Google Scholar 

  3. Perfect, J. R. et al. Clin. Infect. Dis. 50, 291–322 (2010).

    Article  PubMed  Google Scholar 

  4. Maji, A. et al. Nature 623, 1079–1085 (2023).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Berman, J. & Krysan, D. J. Nat. Rev. Microbiol. 18, 319–331 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Delarze, E. & Sanglard, D. Drug Resist. Updat. 23, 12–19 (2015).

    Article  PubMed  Google Scholar 

  7. Rosenberg, A. et al. Nat. Commun. 9, 2470 (2018).

    Article  ADS  PubMed  PubMed Central  Google Scholar 

  8. Levinson, T. et al. Mycoses 64, 78–85 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Rueda, C. et al. Clin. Microbiol. Infect. 23, 49.e1–49.e8 (2017).

    Article  CAS  PubMed  Google Scholar 

  10. Lee, M. K. et al. Mycoses 50, 148–149 (2007).

    Article  CAS  PubMed  Google Scholar 

  11. Yang, F. et al. mBio 14, e0022723 (2023).

  12. Robbins, N., Wright, G. D. & Cowen, L. E. Microbiol. Spectr. (2016).

  13. Shaw, K. J. & Ibrahim, A. S. J. Fungi (2020).

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Correspondence to Judith Berman.

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M.R. is a founder and a shareholder of Elitpca Ltd. All other authors declare no competing interests.

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Mottola, A., Hartl, J., Ralser, M. et al. Metabolic sensing tips the balance of drug tolerance in fungal meningitis. Nat Microbiol 9, 316–317 (2024).

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