Dietary fibre deprivation in mice increases the abundance of gut microbial mucin-degrading species, leads to barrier dysfunction and increases local type 2 inflammation. In a tractable human microbiota mouse model, the presence of Akkermansia muciniphila results in increased anti-commensal IgE and type 2 immune responses, worsening food allergy symptoms following sensitization.
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Akdis, C. A. Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions? Nat. Rev. Immunol. 21, 739–751 (2021). An extremely important review article that discusses the concept of epithelial barrier breakdown and allergy.
Desai, M. S. et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell 167, 1339–1353.E21 (2016). This paper shows a link between dietary fibre, the gut microbiota and the mucus barrier in germ-free and gnotobiotic mice.
Shan, M. et al. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342, 447–453 (2013). An elegant study that presents evidence at the genetic level supporting the protective role of mucus to maintain oral tolerance.
Abdel-Gadir, A. et al. Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy. Nat. Med. 25, 1164–1174 (2019). A pioneering study that presented evidence for IgE-coated bacteria in faecal samples from children and mice with allergy.
Aguilera-Lizarraga, J. et al. Local immune response to food antigens drives meal-induced abdominal pain. Nature 590, 151–156 (2021). A groundbreaking paper that demonstrated a link between bacterial infection and barrier breakdown, food allergy and irritable bowel syndrome in both mice and humans.
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This is a summary of: Parrish, A. et al. Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01464-1 (2023).
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A mucin-foraging bacterium modulates breakdown of oral tolerance. Nat Microbiol 8, 1766–1767 (2023). https://doi.org/10.1038/s41564-023-01480-1