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Switching on cyclic di-GMP heterogeneity in Pseudomonas aeruginosa biofilms

Pseudomonas aeruginosa drives heterogeneity of cyclic di-GMP signalling in biofilms as a division-of-labour strategy to maximize colonization and dispersal using the protein HecE.

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Fig. 1: The HecRE molecular switch regulates P. aeruginosa biofilm development and heterogeneity through c-di-GMP.


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This work was supported by National Institutes of Health (NIH) grants GM139537 and AI58433 to C.M.W.

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Correspondence to Christopher M. Waters.

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Gomez, J.B., Waters, C.M. Switching on cyclic di-GMP heterogeneity in Pseudomonas aeruginosa biofilms. Nat Microbiol 8, 1380–1381 (2023).

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