Colonoids derived from adult human stem cells support growth of human enterovirus. Instead of spreading through the epithelium or lysing infected cells, virus is released within intact infected cells. Infected cells are detected by force-sensing ion channels, a mechanism akin to that used for normal turnover of uninfected epithelia.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Majer, A., McGreevy, A. & Booth, T. F. Molecular pathogenicity of enteroviruses causing neurological disease. Front. Microbiol. 11, 540 (2020). A review article that presents the molecular biology and epidemiology of human enteroviruses.
Zulueta-Coarasa, T. & Rosenblatt, J. The role of tissue maturity and mechanical state in controlling cell extrusion. Curr. Opin. Genet. Dev. 72, 1–7 (2022). A review article that presents the mechanisms of cell extrusion.
Gracheva, E. O. & Bagriantsev, S. N. Sensational channels. Cell 184, 6213–6216 (2021). A review article that celebrates the Nobel Prize in force-sensing ion channel research.
Aguilera, E. R. & Pfeiffer, J. K. Strength in numbers: mechanisms of viral co-infection. Virus Res. 265, 43–46 (2019). A comprehensive review article on all known mechanisms of viral spread by co-infection.
Altan-Bonnet, N., Perales, C. & Domingo, E. Extracellular vesicles: vehicles of en bloc viral transmission. Virus Res. 265, 143–149 (2019). A review article that coins the term ‘en bloc spread’ and discusses its profound genetic sequelae.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Moshiri, J. et al. Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01339-5 (2023).
About this article
Cite this article
Live cells infected with Enterovirus A71 are specifically extruded from human colonoids. Nat Microbiol 8, 565–566 (2023). https://doi.org/10.1038/s41564-023-01340-y