Rebound virus in the cerebrospinal fluid revealed viral lineages selected for growth in T cells that were clonally amplified and often distinct from the majority of rebound viral lineages in the blood.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout

References
Sengupta, S. & Siliciano, R. F. Targeting the latent reservoir for HIV-1. Immunity 48, 872–895 (2018). A review article that presents the nature of the HIV-1 latent reservoir and its role as a barrier to a cure.
Bednar, M. M. et al. Diversity and tropism of HIV-1 rebound virus populations in plasma level after treatment discontinuation. J. Infect. Dis. 214, 403–407 (2016). This paper reports that rebound virus in the blood after therapy discontinuation is diverse and adapted to replication in CD4+ T cells.
Joseph, S. B. & Swanstrom, R. The evolution of HIV-1 entry phenotypes as a guide to changing target cells. J. Leukoc. Biol. 103, 421–431 (2018). A review article that presents the characteristics of the HIV-1 envelope protein, how it influences cellular tropism and how it can evolve over the course of infection.
Zhou, S. et al. Unique molecular identifiers and multiplexing amplicons maximize the utility of deep sequencing to critically assess population diversity in RNA viruses. ACS Infect. Dis. 8, 2505–2514 (2022). This paper reports the importance of using unique molecular identifiers in next generation sequencing to overcome limitations such as PCR and sequencing errors and PCR resampling.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Kincer, L. P. et al. Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus. Nat. Microbiol. https://doi.org/10.1038/s41564-022-01306-6 (2023).
Rights and permissions
About this article
Cite this article
Rebound virus in the cerebrospinal fluid reveals a possible HIV-1 reservoir. Nat Microbiol 8, 195–196 (2023). https://doi.org/10.1038/s41564-022-01309-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41564-022-01309-3