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Rebound virus in the cerebrospinal fluid reveals a possible HIV-1 reservoir

Rebound virus in the cerebrospinal fluid revealed viral lineages selected for growth in T cells that were clonally amplified and often distinct from the majority of rebound viral lineages in the blood.

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Fig. 1: Viral populations in the blood and CSF before therapy and after therapy interruption.


  1. Sengupta, S. & Siliciano, R. F. Targeting the latent reservoir for HIV-1. Immunity 48, 872–895 (2018). A review article that presents the nature of the HIV-1 latent reservoir and its role as a barrier to a cure.

    Article  CAS  Google Scholar 

  2. Bednar, M. M. et al. Diversity and tropism of HIV-1 rebound virus populations in plasma level after treatment discontinuation. J. Infect. Dis. 214, 403–407 (2016). This paper reports that rebound virus in the blood after therapy discontinuation is diverse and adapted to replication in CD4+ T cells.

    Article  Google Scholar 

  3. Joseph, S. B. & Swanstrom, R. The evolution of HIV-1 entry phenotypes as a guide to changing target cells. J. Leukoc. Biol. 103, 421–431 (2018). A review article that presents the characteristics of the HIV-1 envelope protein, how it influences cellular tropism and how it can evolve over the course of infection.

    Article  CAS  Google Scholar 

  4. Zhou, S. et al. Unique molecular identifiers and multiplexing amplicons maximize the utility of deep sequencing to critically assess population diversity in RNA viruses. ACS Infect. Dis. 8, 2505–2514 (2022). This paper reports the importance of using unique molecular identifiers in next generation sequencing to overcome limitations such as PCR and sequencing errors and PCR resampling.

    Article  CAS  Google Scholar 

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This is a summary of: Kincer, L. P. et al. Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus. Nat. Microbiol. (2023).

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Rebound virus in the cerebrospinal fluid reveals a possible HIV-1 reservoir. Nat Microbiol 8, 195–196 (2023).

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