A computational analysis of biosynthetic gene clusters with unique structural features unveils new natural product scaffolds, leading to the discovery of an antibiotic targeting BamA with activity against Gram-negative pathogens.
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The authors declare no competing interests.
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Muñoz, K.A., Hergenrother, P.J. Computational discovery of dynobactin antibiotics. Nat Microbiol 7, 1512–1513 (2022). https://doi.org/10.1038/s41564-022-01234-5