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BACTERIAL GENETICS

Gene essentiality evolves across a pangenome

Genomics analyses of the Streptococcus pneumoniae pangenome show that gene essentiality depends on genetic context and can evolve over time.

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Fig. 1: Gene essentiality can vary across genomes in a pangenome.

References

  1. Tettelin, H. et al. Proc. Natl Acad. Sci USA 102, 13950–13955 (2005).

    Article  CAS  Google Scholar 

  2. Domingo-Sananes, M. R. & McInerney, J. O. Trends Microbiol. 29, 493–503 (2021).

    Article  CAS  Google Scholar 

  3. McInerney, J. O., McNally, A. & O’Connell, M. J. Nat. Microbiol. 2, 17040 (2017).

    Article  CAS  Google Scholar 

  4. Rosconi, F. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-022-01208-7 (2022).

    Article  PubMed  Google Scholar 

  5. Vos, M. & Eyre-Walker, A. Nat. Microbiol. 2, 1576 (2017).

    Article  CAS  Google Scholar 

  6. Whelan, F. J., Hall, R. J. & McInerney, J. O. Mol. Biol. Evol. 38, 3697–3708 (2021).

    Article  CAS  Google Scholar 

  7. Hall, R. J. et al. Microb. Genom. https://doi.org/10.1099/mgen.0.000650 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Hall, R. J. et al. Front. Microbiol. 11, 1569 (2020).

    Article  Google Scholar 

  9. Rancati, G. et al. Nat. Rev. Genet. 19, 34–49 (2018).

    Article  CAS  Google Scholar 

  10. Whelan, F. J., Rusilowicz, M. & McInerney, J. O. Microb. Genom. https://doi.org/10.1099/mgen.0.000338 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Alan J. S. Beavan.

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Beavan, A.J.S., McInerney, J.O. Gene essentiality evolves across a pangenome. Nat Microbiol 7, 1510–1511 (2022). https://doi.org/10.1038/s41564-022-01231-8

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  • DOI: https://doi.org/10.1038/s41564-022-01231-8

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