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ILC3 pyroptosis limits Salmonella infection

Enteric Salmonella not only activates the ILC3–IL-22 axis upon infection to provide a competitive advantage over resident microbiota but also invades ILC3s and induces inflammatory cell death, thus limiting infection.

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Fig. 1: Biphasic response of ILC3s to enteric Salmonella infection.


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Correspondence to Gregory F. Sonnenberg.

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Joseph, A.M., Sonnenberg, G.F. ILC3 pyroptosis limits Salmonella infection. Nat Microbiol 7, 933–934 (2022).

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