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HOST RESPONSE

ILC3 pyroptosis limits Salmonella infection

Enteric Salmonella not only activates the ILC3–IL-22 axis upon infection to provide a competitive advantage over resident microbiota but also invades ILC3s and induces inflammatory cell death, thus limiting infection.

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Fig. 1: Biphasic response of ILC3s to enteric Salmonella infection.

References

  1. Xiong, L. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-022-01142-8 (2022).

  2. Kayama, H., Okumura, R. & Takeda, K. Annu. Rev. Immunol. 38, 23–48 (2020).

    Article  CAS  Google Scholar 

  3. Diefenbach, A., Gnafakis, S. & Shomrat, O. Immunity 52, 452–463 (2020).

    Article  CAS  Google Scholar 

  4. Keir, M., Yi, Y., Lu, T. & Ghilardi, N. J. Exp. Med. 217, e20192195 (2020).

    Article  Google Scholar 

  5. Behnsen, J. et al. Immunity 40, 262–273 (2014).

    Article  CAS  Google Scholar 

  6. Kesavardhana, S., Malireddi, R. K. S. & Kanneganti, T. D. Annu. Rev. Immunol. 38, 567–595 (2020).

    Article  CAS  Google Scholar 

  7. Hu, J. J. et al. Nat. Immunol. 21, 736–745 (2020).

    Article  CAS  Google Scholar 

  8. Pham, O. H. & McSorley, S. J. Future Microbiol. 10, 101–110 (2015).

    Article  CAS  Google Scholar 

  9. Fawkner-Corbett, D. et al. Cell 184, 810–826e823 (2021).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Gregory F. Sonnenberg.

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Joseph, A.M., Sonnenberg, G.F. ILC3 pyroptosis limits Salmonella infection. Nat Microbiol 7, 933–934 (2022). https://doi.org/10.1038/s41564-022-01165-1

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