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ANTIMICROBIALS

Gene–drug potency screening in M. tuberculosis

Large-scale CRISPRi chemical genetic screening in Mycobacterium tuberculosis identifies genes altering antibiotic potency and the repurposing of the antibiotic clarithromycin to treat tuberculosis in Southeast Asia.

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Fig. 1: CRISPRi screen in M. tuberculosis and examples of the identified gene–drug interaction hits.

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Correspondence to Luiz Pedro Sório de Carvalho.

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de Carvalho, L.P.S. Gene–drug potency screening in M. tuberculosis. Nat Microbiol 7, 743–744 (2022). https://doi.org/10.1038/s41564-022-01139-3

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