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Designed secretion deters microbiome depletion

Bacteria can be engineered to degrade antibiotics in the gut, maintaining colonization resistance against pathogenic bacteria and constraining the expansion of antibiotic resistance genes in mice.

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Fig. 1: Lactococcus lactis spTEM1 degrades intestinal ampicillin to overcome the unintended consequences of antibiotics.


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Correspondence to Peter J. Turnbaugh.

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Olson, C.A., Turnbaugh, P.J. Designed secretion deters microbiome depletion. Nat Microbiol 7, 745–746 (2022).

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