Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

MICROBIOME

Designed secretion deters microbiome depletion

Bacteria can be engineered to degrade antibiotics in the gut, maintaining colonization resistance against pathogenic bacteria and constraining the expansion of antibiotic resistance genes in mice.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Lactococcus lactis spTEM1 degrades intestinal ampicillin to overcome the unintended consequences of antibiotics.

References

  1. Blaser, M. J. Science 352, 544–545 (2016).

    CAS  Article  Google Scholar 

  2. Cubillos-Ruiz, A. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00871-9 (2022).

    Article  PubMed  Google Scholar 

  3. Groussin, M. et al. Cell 184, 2053–2067.e18 (2021).

    CAS  Article  Google Scholar 

  4. Chan, C. T. Y., Lee, J. W., Cameron, D. E., Bashor, C. J. & Collins, J. J. Nat. Chem. Biol. 12, 82–86 (2016).

    CAS  Article  Google Scholar 

  5. Hand, T. W. Trends Immunol. 37, 647–658 (2016).

    CAS  Article  Google Scholar 

  6. Wright, G. D. Nat. Rev. Microbiol. 5, 175–186 (2007).

    CAS  Article  Google Scholar 

  7. Ng, K. M. et al. Nature 502, 96–99 (2013).

    CAS  Article  Google Scholar 

  8. Maier, L. et al. Nature 555, 623–628 (2018).

    CAS  Article  Google Scholar 

  9. Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R. & Goodman, A. L. Nature 570, 462–467 (2019).

    CAS  Article  Google Scholar 

  10. Boussios, S., Pentheroudakis, G., Katsanos, K. & Pavlidis, N. Ann. Gastroenterol. Hepatol. 25, 106–118 (2012).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter J. Turnbaugh.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Olson, C.A., Turnbaugh, P.J. Designed secretion deters microbiome depletion. Nat Microbiol 7, 745–746 (2022). https://doi.org/10.1038/s41564-022-01138-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-022-01138-4

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing