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IMMUNE EVASION

Shigella handcuffs caspases

Shigella uses the OspC3 type III secretion system effector to catalyze ADP riboxanation of caspases-4 and 11, preventing lipopolysaccharide recognition and pyroptotic death of the infected cell.

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Fig. 1: ADP riboxanation prevents pyroptosis.

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Correspondence to Edward A. Miao.

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Wei, B., Miao, E.A. Shigella handcuffs caspases. Nat Microbiol 7, 20–21 (2022). https://doi.org/10.1038/s41564-021-01033-4

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  • DOI: https://doi.org/10.1038/s41564-021-01033-4

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