Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

A vision for spaceflight microbiology to enable human health and habitat sustainability

Microbiological research has made important discoveries about how life responds to non-terrestrial environments, such as those found aboard the International Space Station. As human space exploration transitions to longer, deep-space missions, microorganisms will continue to play an increasingly critical role in astronaut health, habitat sustainability and mission success.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Reduced gravity environments associated with spaceflight.

References

  1. Yang, J. et al. in Methods in Microbiology Vol. 45 (eds Gurtler, V. & Trevors, J. T.) Ch. 1 (Academic Press, 2018).

  2. Wilson, J. W. et al. Proc. Natl Acad. Sci. USA 104, 16299–16304 (2007).

    Article  CAS  Google Scholar 

  3. Gilbert, R. et al. NPJ Microgravity 6, 4 (2020).

    Article  Google Scholar 

  4. Nickerson, C. A., Pellis, N. R. & Ott, C. M. (eds) Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms (Springer, 2016).

  5. Nickerson, C. A., Ott, C. M., Wilson, J. W., Ramamurthy, R. & Pierson, D. L. Microbiol. Mol. Biol. Rev. 68, 345–361 (2004).

    Article  CAS  Google Scholar 

  6. Nickerson, C. A. et al. Infect. Immun. 68, 3147–3152 (2000).

    Article  CAS  Google Scholar 

  7. Singh, N. K., Wood, J. M., Karouia, F. & Venkateswaran, K. Microbiome 6, 204 (2018).

    Article  Google Scholar 

  8. Wilson, J. W. et al. PLoS ONE 3, e3923 (2008).

    Article  Google Scholar 

  9. Ott, C. M. et al. in Stress Challenges and Immunity in Space: From Mechanisms to Monitoring and Preventive Strategies (ed Choukèr, A.) 327–355 (Springer International Publishing, 2020).

  10. Kim, W. et al. PLoS ONE 8, e62437 (2013).

    Article  CAS  Google Scholar 

  11. Leveson-Gower, D., McLean,R. J. C. & Nickerson, C. A. Bacterial Adhesion and Corrosion (SpaceX-21) (NASA, 2020); https://www.nasa.gov/ames/research/space-biosciences/bacterial-adhesion-and-corrosion-spacex-21

  12. Stodieck, L. S., Klaus, D. M., Moeller, R., Muecklich, F. & Zea, L. Characterization of Biofilm Formation, Growth, and Gene Expression on Different Materials and Environmental Conditions in Microgravity (NASA, 2021); https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=7955

  13. Garrett-Bakelman, F. E. et al. Science 364, eaau8650 (2019).

    Article  CAS  Google Scholar 

  14. Ichijo, T., Yamaguchi, N., Tanigaki, F., Shirakawa, M. & Nasu, M. NPJ Microgravity 2, 16007 (2016).

    Article  Google Scholar 

  15. Turroni, S. et al. Front. Physiol. https://doi.org/10.3389/fphys.2020.553929 (2020).

  16. Stahl-Rommel, S. et al. Genes 12, 106 (2021).

    Article  CAS  Google Scholar 

  17. Oubre, C. M., Pierson, D. L. & Ott, C. M. in Space Physiology and Medicine: From Evidence to Practice (eds Nicogossian, A. E., Williams, R. S., Huntoon, C. L., Doarn, C. R., Polk, J. D. & Schneider, V. S.) 155–167 (Springer, 2016).

Download references

Acknowledgements

C.A.N., J.B. and C.M.O. were funded by NASA grants NNX15AL06G, NNX17AC79G, 80NSSC18K1478 (includes NASA PECASE funding to J.B.) and 80NSSC20K0016. Many of the topics discussed here were the focus of a Nature conference, The Microbiology of Human Spaceflight, held at the NASA Johnson Space Center in June, 2019; we thank the participants of that conference for their ideas and discussions (https://www.nasa.gov/feature/the-microbiology-of-human-spaceflight-conference-proceedings).

Author information

Authors and Affiliations

Authors

Contributions

C.A.N. and C.M.O. drafted the manuscript. All authors contributed to the revisions and final draft of the manuscript.

Corresponding author

Correspondence to Cheryl A. Nickerson.

Ethics declarations

Competing interests

C.A.N. is the editor-in-chief for npj Microgravity, C.M.O. is deputy editor and J.B. is an editor.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nickerson, C.A., Medina-Colorado, A.A., Barrila, J. et al. A vision for spaceflight microbiology to enable human health and habitat sustainability. Nat Microbiol 7, 471–474 (2022). https://doi.org/10.1038/s41564-021-01015-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-021-01015-6

This article is cited by

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology