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ANTIMICROBIALS

Achilles’ heel of antibiotic resistance

A Publisher Correction to this article was published on 15 November 2021

This article has been updated

Infections caused by antibiotic-resistant bacteria are increasingly prevalent and difficult to treat. A new study identifies the unique vulnerabilities of a class of antibiotic-resistant mutants at the genomic scale, giving new insights into drugs that can be used in combination with antibiotics to suppress resistance.

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Fig. 1: Approach to identify unique vulnerabilities of antibiotic-resistant strains.

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References

  1. CDC. Antibiotic Resistance Threats in the United States 2019 (US Department of Health and Human Services, CDC, 2019).

  2. Baym, M., Stone, L. K. & Kishony, R. Science 351, aad3292 (2016).

    Article  Google Scholar 

  3. Rasouly, A. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-021-00973-1 (2021).

  4. Adams, R. A. et al. J. Antibiot. (Tokyo) https://doi.org/10.1038/s41429-021-00462-x (2021).

  5. Cain, A. K. et al. Nat. Rev. Gen. 21, 526–540 (2020).

    Article  CAS  Google Scholar 

  6. Boehme, C. C. et al. New Engl. J. Med. 363, 1005–1015 (2010).

    Article  CAS  Google Scholar 

  7. MacLean, R. C. & San Millan, A. Science 365, 1082–1083 (2019).

    Article  CAS  Google Scholar 

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Acknowledgements

The author is supported by the Intramural Research Program of the NIH, National Cancer Institute (NCI), Center for Cancer Research.

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Correspondence to Anupama Khare.

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The author declares no competing interests.

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Khare, A. Achilles’ heel of antibiotic resistance. Nat Microbiol 6, 1339–1340 (2021). https://doi.org/10.1038/s41564-021-00985-x

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