Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Achilles’ heel of antibiotic resistance

A Publisher Correction to this article was published on 15 November 2021

This article has been updated

Infections caused by antibiotic-resistant bacteria are increasingly prevalent and difficult to treat. A new study identifies the unique vulnerabilities of a class of antibiotic-resistant mutants at the genomic scale, giving new insights into drugs that can be used in combination with antibiotics to suppress resistance.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Approach to identify unique vulnerabilities of antibiotic-resistant strains.

Change history


  1. CDC. Antibiotic Resistance Threats in the United States 2019 (US Department of Health and Human Services, CDC, 2019).

  2. Baym, M., Stone, L. K. & Kishony, R. Science 351, aad3292 (2016).

    Article  Google Scholar 

  3. Rasouly, A. et al. Nat. Microbiol. (2021).

  4. Adams, R. A. et al. J. Antibiot. (Tokyo) (2021).

  5. Cain, A. K. et al. Nat. Rev. Gen. 21, 526–540 (2020).

    Article  CAS  Google Scholar 

  6. Boehme, C. C. et al. New Engl. J. Med. 363, 1005–1015 (2010).

    Article  CAS  Google Scholar 

  7. MacLean, R. C. & San Millan, A. Science 365, 1082–1083 (2019).

    Article  CAS  Google Scholar 

Download references


The author is supported by the Intramural Research Program of the NIH, National Cancer Institute (NCI), Center for Cancer Research.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Anupama Khare.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Khare, A. Achilles’ heel of antibiotic resistance. Nat Microbiol 6, 1339–1340 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing