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Dual-mechanism antibiotics

A dual-mechanism compound with antibacterial activity that targets both folate metabolism and membrane integrity, with a favourable resistance profile in vitro, is identified by screening a small molecule library.

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Fig. 1: Dual-mechanism approaches.


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Correspondence to Ursula Theuretzbacher.

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Theuretzbacher, U. Dual-mechanism antibiotics. Nat Microbiol 5, 984–985 (2020).

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