A dual-mechanism compound with antibacterial activity that targets both folate metabolism and membrane integrity, with a favourable resistance profile in vitro, is identified by screening a small molecule library.
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Wang, K. K. et al. Mol. Biol. Evol. 33, 492–500 (2016).
Martin, J. K. II et al. Cell 181, 1518–1532 (2020).
Bremner, J. B., Ambrus, J. I. & Samosorn, S. Curr. Med. Chem. 14, 1459–1477 (2007).
Jubeh, B., Breijyeh, Z. & Karaman, R. Molecules 25, 1543 (2020).
Page, M. G. P. Clin. Infect. Dis. 69 (Suppl. 7), S529–S537 (2019).
Gupta, V. & Datta, P. Indian J. Med. Res. 149, 97–106 (2019).
Liu, L. et al. Molecules 24, 1641 (2019).
Ma, Z. & Lynch, A. S. J. Med. Chem. 59, 6645–6657 (2016).
Domalaon, R., Idowu, T., Zhanel, G. G. & Schweizer, F. Clin. Microbiol. Rev. 31, e00077-17 (2018).
Parkes, A. L. & Yule, I. A. Expert Opin. Drug Discov. 11, 665–680 (2016).
The author declares no competing interests.
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Theuretzbacher, U. Dual-mechanism antibiotics. Nat Microbiol 5, 984–985 (2020). https://doi.org/10.1038/s41564-020-0767-0