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HOST RESPONSE

Cholesterol access aids pathogen spread

Nature Microbiology volume 5, pages 881–882 (2020)Cite this article

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Some cytosolic bacteria deform the plasma membrane to spread from cell to cell. Secretion of 25-hydroxy-cholesterol by macrophages has emerged as a protective response that depletes the cholesterol pool used by these bacteria to disseminate through epithelia.

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Fig. 1: Oxysterol-mediated host protection against cytosolic bacteria.

References

  1. Abrams, M. E. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-020-0701-5 (2020).

    Article  PubMed  Google Scholar 

  2. Ray, K., Marteyn, B., Sansonetti, P. J. & Tang, C. M. Nat. Rev. Microbiol. 7, 333–340 (2009).

    Article  CAS  Google Scholar 

  3. Chang, T. Y. et al. Curr. Opin. Lipidol. 12, 289–296 (2001).

    Article  CAS  Google Scholar 

  4. Hilgemann, D. W. et al. J. Gen. Physiol. 150, 211–224 (2018).

    Article  CAS  Google Scholar 

  5. Corrotte, M. et al. eLife 2, e00926 (2013).

    Article  Google Scholar 

  6. Hubert, M. et al. eLife 9, e55038 (2020).

    Article  Google Scholar 

  7. Sinha, B. et al. Cell 144, 402–413 (2011).

    Article  CAS  Google Scholar 

  8. Chávez-Arroyo, A. & Portnoy, D. A. Cell. Microbiol. 22, e13175 (2020).

    Article  Google Scholar 

  9. Schuchman, E. H. FEBS Lett. 584, 1895–1900 (2010).

    Article  CAS  Google Scholar 

  10. Henry, R. et al. Cell. Microbiol. 8, 107–119 (2006).

    Article  CAS  Google Scholar 

  11. Melton-Witt, J. A., Rafelski, S. M., Portnoy, D. A. & Bakardjiev, A. I. Infect. Immun. 80, 720–732 (2012).

    Article  CAS  Google Scholar 

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  1. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA

    Norma W. Andrews

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  1. Norma W. Andrews
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Correspondence to Norma W. Andrews.

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The author declares no competing interests.

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Andrews, N.W. Cholesterol access aids pathogen spread. Nat Microbiol 5, 881–882 (2020). https://doi.org/10.1038/s41564-020-0744-7

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