Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

MICROBIOME

Microbial colonization alters neonatal gut metabolome

Multi-omics reveals how metabolites produced by pioneer bacterial species might alter the neonatal gut environment to an anaerobic state much earlier than was previously thought during the first hours of life.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Model of neonatal microbiome dynamics.

References

  1. Righetti, C., Peroni, D. G., Pietrobelli, A. & Zancanaro, C. J. Pediatr. Gastroenterol. Nutr. 36, 498–501 (2003).

    Article  CAS  Google Scholar 

  2. Aziz, S. et al. Acta Paediatr. 90, 81–87 (2001).

    Article  CAS  Google Scholar 

  3. Kinsella, R. A. Jr & Francis, F. E. J. Clin. Endocrinol. Metab. 32, 801–818 (1971).

    Article  CAS  Google Scholar 

  4. Yatsunenko, T. et al. Nature 486, 222–227 (2012).

    Article  CAS  Google Scholar 

  5. Bittinger, K. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-020-0694-0 (2020).

  6. Favier, C. F., Vaughan, E. E., Vos, W. M. D. & Akkermans, A. D. L. Appl. Environ. Microbiol. 68, 219–226 (2002).

    Article  CAS  Google Scholar 

  7. Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A. & Brown, P. O. PLoS Biol. 5, e177 (2007).

    Article  Google Scholar 

  8. Dominguez-Bello, M. G. et al. Proc. Natl Acad. Sci. USA 107, 11971–11975 (2010).

    Article  Google Scholar 

  9. Bäckhed, F. et al. Cell Host Microbe 17, 690–703 (2015).

    Article  Google Scholar 

  10. Combellick, J. L. et al. Sci. Rep. 8, 15660 (2018).

    Article  Google Scholar 

  11. Ferretti, P. et al. Cell Host Microbe 24, 133–145 (2018).

    Article  CAS  Google Scholar 

  12. Stark, P. L. & Lee, A. J. Med. Microbiol. 15, 189–203 (1982).

    Article  CAS  Google Scholar 

  13. Jost, T., Lacroix, C., Braegger, C. P. & Chassard, C. PLoS ONE 7, e44595 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Jincheng Wang or Maria Gloria Dominguez-Bello.

Ethics declarations

Competing interests

M.G.D.-B. has intellectual rights in the New York University US patent no. 10357521 related to methods for restoring the microbiota of newborns. The remaining author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, J., Dominguez-Bello, M.G. Microbial colonization alters neonatal gut metabolome. Nat Microbiol 5, 785–786 (2020). https://doi.org/10.1038/s41564-020-0734-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-020-0734-9

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology