PARASITE DEVELOPMENT

Mastering Toxoplasma sex and sleep

Two studies now identify bradyzoite-formation deficient 1 and microrchidia as ‘master regulators’ of the transcriptional events that control developmental life cycle transitions in the protozoan parasite Toxoplasma gondii.

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Fig. 1: Master regulators modulating sleep and sex during the life cycle of T. gondii parasites.

References

  1. 1.

    Martynowicz, J., Augusto, L., Wek, R. C., Boehm, S. L. II & Sullivan, W. J. Jr. mBio 10, e00381-19 (2019).

  2. 2.

    Tyebji, S., Seizova, S., Hannan, A. J. & Tonkin, C. J. Neurosci. Biobehav. Rev. 96, 72–92 (2019).

  3. 3.

    Dixon, S. E., Stilger, K. L., Elias, E. V., Naguleswaran, A. & Sullivan, W. J. Jr Mol. Biochem. Parasitol. 173, 1–9 (2010).

  4. 4.

    Balaji, S., Babu, M. M., Iyer, L. M. & Aravind, L. Nucleic Acids Res. 33, 3994–4006 (2005).

  5. 5.

    Painter, H. J., Campbell, T. L. & Llinas, M. Mol. Biochem. Parasitol. 176, 1–7 (2011).

  6. 6.

    Gissot, M., Briquet, S., Refour, P., Boschet, C. & Vaquero, C. J. Mol. Biol. 346, 29–42 (2005).

  7. 7.

    Jeffers, V., Tampaki, Z., Kim, K. & Sullivan, W. J. Jr Cell. Mol. Life Sci. 75, 2355–2373 (2018).

  8. 8.

    Waldman, B. S. et al. Cell 180, 359–372 (2020).

  9. 9.

    Farhat, D. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-020-0674-4 (2020).

  10. 10.

    Holmes, M. J., Augusto, L. D. S., Zhang, M., Wek, R. C. & Sullivan, W. J. Jr Trends Parasitol. 33, 947–960 (2017).

  11. 11.

    Hunter, C. A. et al. Nat. Rev. Microbiol. 10, 766–778 (2012).

  12. 12.

    Frenal, K. et al. Nat. Rev. Microbiol. 15, 645–660 (2017).

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Correspondence to William J. Sullivan Jr.

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Sullivan, W.J. Mastering Toxoplasma sex and sleep. Nat Microbiol 5, 533–534 (2020). https://doi.org/10.1038/s41564-020-0696-y

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