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Crosstalking second messengers

By competing for the same binding site on SmbA, a regulatory nucleotide-binding protein, the bacterial second messengers c-di-GMP and (p)ppGpp inversely balance cell cycle re-entry of growth-arrested swarmer cells of Caulobacter crescentus.

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Fig. 1: Regulation of the cell cycle of C. crescentus by second messengers.


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Correspondence to Regine Hengge.

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Hengge, R. Crosstalking second messengers. Nat Microbiol 6, 9–10 (2021).

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