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BACTERIAL PATHOGENESIS

Commensal pneumococci go nuclear

Commensal pneumococci convert invasive diseases to peaceful colonizers by commandeering the host nuclear KDM6B demethylase to mark NF-κB sites of the IL-11 cytokine promoter and increase epithelium repair.

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Fig. 1: Commensal pneumococci modulate host epigenetics to increase IL-11 production and conserve epithelial integrity.

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Correspondence to Elaine I. Tuomanen.

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Tuomanen, E.I. Commensal pneumococci go nuclear. Nat Microbiol 6, 143–144 (2021). https://doi.org/10.1038/s41564-020-00829-0

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