Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Commensal pneumococci go nuclear

Commensal pneumococci convert invasive diseases to peaceful colonizers by commandeering the host nuclear KDM6B demethylase to mark NF-κB sites of the IL-11 cytokine promoter and increase epithelium repair.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Commensal pneumococci modulate host epigenetics to increase IL-11 production and conserve epithelial integrity.


  1. 1.

    Connor, M. G. et al. Nat. Microbiol. (2020).

  2. 2.

    Bierne, H. & Cossart, P. Cell. Microbiol. 14, 622–633 (2012).

    CAS  Article  Google Scholar 

  3. 3.

    Rolando, M. et al. Cell. Microbiol. 17, 1098–1107 (2015).

    CAS  Article  Google Scholar 

  4. 4.

    Grabiec, A. M. & Potempa, J. Crit. Rev. Microbiol. 44, 336–350 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Mujtaba, S. et al. J. Biol. Chem. 288, 23458–23472 (2013).

    CAS  Article  Google Scholar 

  6. 6.

    Silmon de Monerri, N. C. & Kim, K. Am. J. Pathol. 184, 897–911 (2014).

    CAS  Article  Google Scholar 

  7. 7.

    Adhikari, S. & Curtis, P. D. FEMS Microbiol. Rev. 40, 575–591 (2016).

    CAS  Article  Google Scholar 

  8. 8.

    Ciarlo, E., Savva, A. & Roger, T. Int. J. Antimicrob. Agents 42 (Suppl.), S8–12 (2013).

Download references

Author information



Corresponding author

Correspondence to Elaine I. Tuomanen.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tuomanen, E.I. Commensal pneumococci go nuclear. Nat Microbiol 6, 143–144 (2021).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing