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BACTERIAL PATHOGENESIS

Commensal pneumococci go nuclear

Commensal pneumococci convert invasive diseases to peaceful colonizers by commandeering the host nuclear KDM6B demethylase to mark NF-κB sites of the IL-11 cytokine promoter and increase epithelium repair.

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Fig. 1: Commensal pneumococci modulate host epigenetics to increase IL-11 production and conserve epithelial integrity.

References

  1. Connor, M. G. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-020-00805-8 (2020).

  2. Bierne, H. & Cossart, P. Cell. Microbiol. 14, 622–633 (2012).

    Article  CAS  Google Scholar 

  3. Rolando, M. et al. Cell. Microbiol. 17, 1098–1107 (2015).

    Article  CAS  Google Scholar 

  4. Grabiec, A. M. & Potempa, J. Crit. Rev. Microbiol. 44, 336–350 (2018).

    Article  CAS  Google Scholar 

  5. Mujtaba, S. et al. J. Biol. Chem. 288, 23458–23472 (2013).

    Article  CAS  Google Scholar 

  6. Silmon de Monerri, N. C. & Kim, K. Am. J. Pathol. 184, 897–911 (2014).

    Article  CAS  Google Scholar 

  7. Adhikari, S. & Curtis, P. D. FEMS Microbiol. Rev. 40, 575–591 (2016).

    Article  CAS  Google Scholar 

  8. Ciarlo, E., Savva, A. & Roger, T. Int. J. Antimicrob. Agents 42 (Suppl.), S8–12 (2013).

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Correspondence to Elaine I. Tuomanen.

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Tuomanen, E.I. Commensal pneumococci go nuclear. Nat Microbiol 6, 143–144 (2021). https://doi.org/10.1038/s41564-020-00829-0

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