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MICROBIOME

How to thrive in the inflamed gut

Metabolic adaptation plays a key role in determining the composition of microbial ecosystems. A new study shows that in the inflamed gut, pathogenic Enterobacteriaceae can reprogramme their metabolism towards diet-derived l-serine utilization to outcompete the resident microbiota and cause disease.

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Fig. 1: Dietary l-serine fuels Enterobacteriaceae expansion in the inflamed gut.

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Correspondence to Mariana X. Byndloss.

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Yoo, W., Byndloss, M.X. How to thrive in the inflamed gut. Nat Microbiol 5, 10–11 (2020). https://doi.org/10.1038/s41564-019-0642-z

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