VIRAL INFECTION

Phages build anti-defence barriers

Two recent studies reveal a virus anti-defence strategy whereby large, ‘jumbo’ phages protect themselves from both restriction endonucleases and DNA-targeting CRISPR–Cas systems, but not from RNA-targeting ones, by encapsulating the phage genome inside the cell in a ‘nucleus’-like shell that is impenetrable for CRISPR effectors.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: ‘Nucleus’-like organelles in host defence and virus anti-defence.

References

  1. 1.

    Hille, F. et al. Cell 172, 1239–1259 (2018).

  2. 2.

    Pawluk, A., Davidson, A. R. & Maxwell, K. L. Nat. Rev. Microbiol. 16, 12–17 (2018).

  3. 3.

    Mendoza, S. D. et al. Nature https://doi.org/10.1038/s41586-019-1786-y (2019).

  4. 4.

    Malone, L. M. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0612-5 (2019).

  5. 5.

    Chaikeeratisak, V. et al. Science 355, 194–197 (2017).

  6. 6.

    Chaikeeratisak, V. et al. Cell Rep. 20, 1563–1571 (2017).

  7. 7.

    Erb, M. L. et al. eLife 3, e03197 (2014).

  8. 8.

    Silas, S. et al. Science 351, aad4234 (2016).

  9. 9.

    Al­Shayeb, B. et al. Preprint at https://doi.org/10.1101/572362 (2019).

  10. 10.

    Ahola, T. mBio 10, e01402-19 (2019).

  11. 11.

    Mutsafi, Y., Fridmann-Sirkis, Y., Milrot, E., Hevroni, L. & Minsky, A. Virology 466–467, 3–14 (2014).

  12. 12.

    Koonin, E. V., Dolja, V. V. & Krupovic, M. Virology 479–480, 2–25 (2015).

  13. 13.

    Kennaway, C. K. et al. Gene Dev. 26, 92–104 (2012).

Download references

Author information

Correspondence to Eugene V. Koonin or Mart Krupovic.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Koonin, E.V., Krupovic, M. Phages build anti-defence barriers. Nat Microbiol 5, 8–9 (2020). https://doi.org/10.1038/s41564-019-0635-y

Download citation