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VACCINES

Neuraminidase escape attempts

Nature Microbiology volume 4, pages 2031–2032 (2019)Cite this article

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Influenza vaccine strain selection is informed by international efforts to track antigenic change, focusing on the viral hemagglutinin protein. Recent research advocates monitoring neuraminidase for immune escape mutations that could reduce vaccine efficacy.

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Fig. 1: Influenza A/H3N2 virus NA glycosylation adjacent to the catalytic site facilitates escape from NI antibodies and could compromise protection.

graphs (right) adapted from nextstrain.org, data source GISAID

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Authors and Affiliations

  1. WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

    Annette Fox & Louise Carolan

Authors
  1. Annette Fox
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  2. Louise Carolan
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Correspondence to Annette Fox.

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The authors declare no competing interests.

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Fox, A., Carolan, L. Neuraminidase escape attempts. Nat Microbiol 4, 2031–2032 (2019). https://doi.org/10.1038/s41564-019-0615-2

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