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ANTIMICROBIAL RESISTANCE

Transient antibiotic resistance calls for attention

Clinicians have long observed that infections diagnosed as susceptible to antibiotics can sometimes resist treatment. New studies show that such treatment failures can be explained by subpopulations of transiently resistant cells that are often missed by standard clinical diagnostics, offering new therapeutic avenues.

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Fig. 1: Heteroresistance emerges from gene amplifications, calling for combined antimicrobial therapy.

References

  1. 1.

    Yelin, I. & Kishony, R. Cell 172, 1136–1136 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Balaban, N. Q. et al. Nat. Rev. Microbiol. 17, 441–448 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Band, V. I. & Weiss, D. S. PLoS Pathog. 15, e1007726 (2019).

    Article  Google Scholar 

  4. 4.

    Andersson, D. I., Nicoloff, H. & Hjort, K. M. Nat. Rev. Microbiol. 17, 479–496 (2019).

    CAS  Article  Google Scholar 

  5. 5.

    Alexander, H. E. & Leidy, G. J. Exp. Med. 85, 329–338 (1947).

    CAS  Article  Google Scholar 

  6. 6.

    Bigger, J. Lancet 244, 497–500 (1944).

    Article  Google Scholar 

  7. 7.

    Nicoloff, H., Hjort, K., Levin, B. R. & Andersson, D. I. Nat. Microbiol. 4, 504–514 (2019).

    CAS  Article  Google Scholar 

  8. 8.

    Band, V. I. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0480-z (2019).

  9. 9.

    Stone, L. K. et al. Nat. Chem. Biol. 12, 902–904 (2016).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Viktória Lázár or Roy Kishony.

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Lázár, V., Kishony, R. Transient antibiotic resistance calls for attention. Nat Microbiol 4, 1606–1607 (2019). https://doi.org/10.1038/s41564-019-0571-x

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