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Phospholipid middle management

The Mla phospholipid transporter is a multi-subunit ATP-binding cassette transport system widely understood to move phospholipids in a retrograde direction; that is, from the outer membrane to the inner membrane. However, recent studies reveal that Mla might move phospholipids in the opposite, anterograde direction.

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Fig. 1: Schematic diagram of the Mla phospholipid transport system.


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Correspondence to Russell E. Bishop.

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Bishop, R.E. Phospholipid middle management. Nat Microbiol 4, 1608–1609 (2019).

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