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Legionella dismantles linear ubiquitin

Host cells assemble linear ubiquitin chains to activate immune signalling during bacterial infection. A new study reveals that Legionella pneumophila — the causative agent of Legionnaires’ disease — produces an enzyme that specifically disassembles these linear ubiquitin modifications to restrict immune responses.

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Fig. 1: Pathogen interference in linear ubiquitin-mediated immune signalling.


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Correspondence to Rune Busk Damgaard or Jonathan N. Pruneda.

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Damgaard, R.B., Pruneda, J.N. Legionella dismantles linear ubiquitin. Nat Microbiol 4, 1244–1245 (2019).

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