News & Views | Published:

ARCHAEAL EVOLUTION

Eukaryogenesis, a syntrophy affair

Eukaryotes evolved from a symbiosis involving Alphaproteobacteria and archaea phylogenetically nested within the Asgard clade. Two recent studies explore the metabolic capabilities of Asgard lineages, supporting refined symbiotic metabolic interactions that might have operated at the dawn of eukaryogenesis.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Ethics declarations

Competing interests

The authors declare no competing interests.

References

  1. 1.

    Martin, W. F., Garg, S. & Zimorski, V. Philos. T. Roy. Soc. B 370, 20140330 (2015).

  2. 2.

    Lopez-Garcia, P. & Moreira, D. Trends Ecol. Evol. 30, 697–708 (2015).

  3. 3.

    Lopez-Garcia, P., Eme, L. & Moreira, D. J. Theor. Biol. 434, 20–33 (2017).

  4. 4.

    Spang, A. et al. Nature 521, 173–179 (2015).

  5. 5.

    Zaremba-Niedzwiedzka, K. et al. Nature 541, 353–358 (2017).

  6. 6.

    Eme, L., Spang, A., Lombard, J., Stairs, C. W. & Ettema, T. J. G. Nat. Rev. Microbiol. 15, 711–723 (2017).

  7. 7.

    López-García, P. & Moreira, D. Trends Biochem. Sci. 24, 88–93 (1999).

  8. 8.

    Spang, A. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0406-9 (2019).

  9. 9.

    Bulzu, P. A. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0404-y (2019).

  10. 10.

    Seitz, K. W. et al. Nat. Commun. 10, 1822 (2019).

  11. 11.

    Pittis, A. A. & Gabaldon, T. Nature 531, 101–104 (2016).

  12. 12.

    Sousa, F. L., Neukirchen, S., Allen, J. F., Lane, N. & Martin, W. F. Nat. Microbiol. 1, 16034 (2016).

  13. 13.

    Berghuis, B. A. et al. Proc. Natl Acad. Sci. USA 116, 5037–5044 (2019).

  14. 14.

    Evans, P. N. et al. Nat. Rev. Microbiol. 17, 219–232 (2019).

Download references

Author information

Competing interests

The authors declare no competing interests.

Correspondence to Purificación López-García.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: Metabolic symbiosis at the origin of eukaryotes.