MICROBIOME

Microbiome genome structure drives function

Differences in microbial genomes can result in vastly different phenotypes and functions. Consequently, it is critical to understand the genome variations that differentiate microbial strains. Here, we discuss recent exciting advances that enable structural variant measurement, their associated phenotypes and the horizon for future discovery.

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Fig. 1: Structural variation in the gut microbiome.

References

  1. 1.

    Zeevi, D. et al. Nature 568, 43–48 (2019).

    CAS  Article  Google Scholar 

  2. 2.

    Korem, T. et al. Science 349, 1101–1106 (2015).

    CAS  Article  Google Scholar 

  3. 3.

    Routy, B. et al. Science 359, 91–97 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Gopalakrishnan, V. et al. Science 359, 97–103 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Matson, V. et al. Science 359, 104–108 (2018).

    CAS  Article  Google Scholar 

  6. 6.

    Bishara, A. et al. Nat. Biotechnol. 36, 1067–1075 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Moss, E. L. & Bhatt, A. S. bioRxiv https://doi.org/10.1101/489641 (2018).

  8. 8.

    Durrant, M., Li, M. M., Siranosian, B. & Bhatt, A. S. bioRxiv https://doi.org/10.1101/527788 (2019).

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Correspondence to Ami S. Bhatt.

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Durrant, M.G., Bhatt, A.S. Microbiome genome structure drives function. Nat Microbiol 4, 912–913 (2019). https://doi.org/10.1038/s41564-019-0473-y

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