The secondary metabolite cepacin A is the essential compound made by Burkholderia ambifaria needed for biocontrol of plant pathogens. In this organism, genes responsible for virulence and for cepacin A biosynthesis reside on different replicons, allowing for the engineering of avirulent mutants that retain their biocontrol properties.
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Coenye, T. Uncoupling virulence and biocontrol. Nat Microbiol 4, 908–909 (2019). https://doi.org/10.1038/s41564-019-0459-9
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DOI: https://doi.org/10.1038/s41564-019-0459-9