News & Views | Published:

VIRAL RESERVOIRS

Bat tolerance to viral infections

Inflammatory molecules evolved partly to protect hosts from viruses, but increasing evidence suggests that they cause disease pathology and chronic conditions, and play a role in aging. By mitigating these effects, bats are able to both tolerate viral infections and live well beyond expectations.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Han, B. A., Kramer, A. M. & Drake, J. M. Trends Parasitol. 32, 565–577 (2016).

  2. 2.

    Olival, K. J. et al. Nature 546, 646 (2017).

  3. 3.

    O’Shea, T. J. et al. Emerg. Infect. Dis. 20, 741 (2014).

  4. 4.

    Zhang, G. et al. Science 339, 456–460 (2013).

  5. 5.

    Ahn, M. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0371-3 (2019).

  6. 6.

    Zhou, P. et al. Proc. Natl Acad. Sci. USA 113, 2696–2701 (2016).

  7. 7.

    Schountz, T., Baker, M. L., Butler, J. & Munster, V. Front. Immunol. 8, 1098 (2017).

  8. 8.

    Pavlovich, S. S. et al. Cell 173, 1098–1110 (2018).

  9. 9.

    Foley, N. M. et al. Science Advances 4, eaao0926 (2018).

  10. 10.

    Munster, V. J. et al. Sci. Rep-UK 6, 21878 (2016).

  11. 11.

    Swanepoel, R. et al. Emerg. Infect. Dis. 2, 321–325 (1996).

  12. 12.

    Dudas, G., Carvalho, L. M., Rambaut, A. & Bedford, T. eLife 7, e31257 (2018).

  13. 13.

    O’Mara, M. T. et al. eLife 6, e26686 (2017).

Download references

Author information

Competing interests

The author declares no competing interests.

Correspondence to David T. S. Hayman.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: Differences in traits related to longevity and infection between bats and other mammals.