Eradicating the viral reservoir remains a formidable barrier to curing human immunodeficiency virus (HIV). The first challenge is to characterize the cells and tissues where HIV hides. In this issue of Nature Microbiology, urethral macrophages are shown to retain infectious HIV particles, prompting us to rethink strategies to eliminate the reservoir.
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Rodrigues, V., Benaroch, P. Macrophages hide HIV in the urethra. Nat Microbiol 4, 556–557 (2019). https://doi.org/10.1038/s41564-019-0418-5
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DOI: https://doi.org/10.1038/s41564-019-0418-5