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VIRAL RESERVOIR

Macrophages hide HIV in the urethra

Eradicating the viral reservoir remains a formidable barrier to curing human immunodeficiency virus (HIV). The first challenge is to characterize the cells and tissues where HIV hides. In this issue of Nature Microbiology, urethral macrophages are shown to retain infectious HIV particles, prompting us to rethink strategies to eliminate the reservoir.

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Fig. 1: HIV reservoirs in infected patients under anti-retroviral therapy.

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Correspondence to Vasco Rodrigues or Philippe Benaroch.

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Rodrigues, V., Benaroch, P. Macrophages hide HIV in the urethra. Nat Microbiol 4, 556–557 (2019). https://doi.org/10.1038/s41564-019-0418-5

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