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BACTERIAL PATHOGENESIS

Chronic infection by controlling inflammation

Molecular players involved in systemic and acute infections are relatively easy to pinpoint, whereas bacterial resilience during chronic infections remains less well understood. Pseudomonas aeruginosa encodes a quorum-regulated virulence factor, TesG, that promotes chronic lung infection by suppressing host inflammatory responses.

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Fig. 1: Model for TesG suppression of inflammation.

References

  1. Smith, W. D. et al. FEMS Microbiol. Lett. 364, fnx121 (2017).

    Article  Google Scholar 

  2. Goodman, A. L. et al. Gene. Dev. 23, 249–259 (2009).

    CAS  Article  Google Scholar 

  3. Moradali, M. F., Ghods, S. & Rehm, B. H. Front. Cell. Infect. Mi. 7, 39 (2017).

    Google Scholar 

  4. Zhao, K. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0322-4 (2019).

    Article  PubMed  Google Scholar 

  5. Holland, I. B. et al. EcoSal Plus https://doi.org/10.1128/ecosalplus.ESP-0019-2015 (2016).

    Article  PubMed  Google Scholar 

  6. Jimenez, P. N. et al. Microbiol. Mol. Biol. R. 76, 46–65 (2012).

    CAS  Article  Google Scholar 

  7. Valentini, M., Gonzalez, D., Mavridou, D. A. & Filloux, A. Curr. Opin. Microbiol. 41, 15–20 (2018).

    CAS  Article  Google Scholar 

  8. Mikkelsen, H. et al. Microbiology 155, 687–698 (2009).

    CAS  Article  Google Scholar 

  9. Jorth, P. et al. Cell Host Microbe 18, 307–319 (2015).

    CAS  Article  Google Scholar 

  10. Cantin, A. M., Hartl, D., Konstan, M. W. & Chmiel, J. F. J. Cyst. Fibros. 14, 419–430 (2015).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Alain Filloux or Jane C. Davies.

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Filloux, A., Davies, J.C. Chronic infection by controlling inflammation. Nat Microbiol 4, 378–379 (2019). https://doi.org/10.1038/s41564-019-0397-6

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