Klebsiella pneumoniae isolated from patients with primary sclerosing cholangitis was found to cause intestinal barrier dysfunction resulting in T-helper-17-cell-mediated hepatobiliary injury, providing evidence for specific gut-derived, pore-forming pathogens as triggers for immune-mediated liver disease.
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The authors declare no competing interests.
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Fickert, P., Marschall, HU. Gut pathobionts as triggers for liver diseases. Nat Microbiol 4, 380–381 (2019). https://doi.org/10.1038/s41564-019-0388-7