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MICROBIOME

Gut commensals make choline too

Nature Microbiologyvolume 4pages45 (2019) | Download Citation

Hydrolysis of phosphatidylcholine to choline was found to be catalysed by phospholipase D enzymes from diverse members of the gut microbiota, revealing a mechanism by which commensals obtain choline for subsequent production of disease-associated trimethylamine.

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Author information

Affiliations

  1. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA

    • Aaron T. Wright
  2. The Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA, USA

    • Aaron T. Wright

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Aaron T. Wright.

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DOI

https://doi.org/10.1038/s41564-018-0325-1

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