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Gut commensals make choline too

Nature Microbiologyvolume 4pages45 (2019) | Download Citation

Hydrolysis of phosphatidylcholine to choline was found to be catalysed by phospholipase D enzymes from diverse members of the gut microbiota, revealing a mechanism by which commensals obtain choline for subsequent production of disease-associated trimethylamine.

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Author information


  1. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA

    • Aaron T. Wright
  2. The Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA, USA

    • Aaron T. Wright


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The authors declare no competing interests.

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Correspondence to Aaron T. Wright.

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