Hydrolysis of phosphatidylcholine to choline was found to be catalysed by phospholipase D enzymes from diverse members of the gut microbiota, revealing a mechanism by which commensals obtain choline for subsequent production of disease-associated trimethylamine.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chittim, L. C., Martinez del Campo, A. & Balskus, E. P. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0294-4 (2018).
Wang, Z. et al. Nature 472, 57–63 (2012).
Tang, W. H. W. et al. N. Engl. J. Med. 368, 1575–1584 (2013).
Romano, K. A., Vivas, E. I., Amador-Noguez, D. & Rey, F. E. mBio 6, e02481-14 (2015).
Bodea, S., Funk, M. A., Balskus, E. P. & Drennan, C. L. Cell Chem. Biol. 23, 1206–1216 (2016).
Koppel, N. & Balskus, E. P. Cell Chem. Biol. 23, 18–30 (2016).
Tropini, C., Earle, K. A., Huang, K. C. & Sonnenburg, J. L. Cell Host Microbe 21, 433–442 (2017).
Bitteen, J. S. et al. ACS Nano 10, 6–37 (2016).
Whidbey, C. & Wright, A. T. Curr. Top. Microbiol. Immunol. http://doi.org/cw6n (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Wright, A.T. Gut commensals make choline too. Nat Microbiol 4, 4–5 (2019). https://doi.org/10.1038/s41564-018-0325-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41564-018-0325-1
This article is cited by
-
Post-stroke depression: epigenetic and epitranscriptomic modifications and their interplay with gut microbiota
Molecular Psychiatry (2023)