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MICROBIOME

Gut commensals make choline too

Hydrolysis of phosphatidylcholine to choline was found to be catalysed by phospholipase D enzymes from diverse members of the gut microbiota, revealing a mechanism by which commensals obtain choline for subsequent production of disease-associated trimethylamine.

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The authors declare no competing interests.

Correspondence to Aaron T. Wright.

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Fig. 1: Gut commensal organisms play an important role in the conversion of choline to disease-associated TMA.