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Gut commensals make choline too

Hydrolysis of phosphatidylcholine to choline was found to be catalysed by phospholipase D enzymes from diverse members of the gut microbiota, revealing a mechanism by which commensals obtain choline for subsequent production of disease-associated trimethylamine.

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  1. 1.

    Chittim, L. C., Martinez del Campo, A. & Balskus, E. P. Nat. Microbiol. (2018).

  2. 2.

    Wang, Z. et al. Nature 472, 57–63 (2012).

  3. 3.

    Tang, W. H. W. et al. N. Engl. J. Med. 368, 1575–1584 (2013).

  4. 4.

    Romano, K. A., Vivas, E. I., Amador-Noguez, D. & Rey, F. E. mBio 6, e02481-14 (2015).

  5. 5.

    Bodea, S., Funk, M. A., Balskus, E. P. & Drennan, C. L. Cell Chem. Biol. 23, 1206–1216 (2016).

  6. 6.

    Koppel, N. & Balskus, E. P. Cell Chem. Biol. 23, 18–30 (2016).

  7. 7.

    Tropini, C., Earle, K. A., Huang, K. C. & Sonnenburg, J. L. Cell Host Microbe 21, 433–442 (2017).

  8. 8.

    Bitteen, J. S. et al. ACS Nano 10, 6–37 (2016).

  9. 9.

    Whidbey, C. & Wright, A. T. Curr. Top. Microbiol. Immunol. (2018).

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The authors declare no competing interests.

Correspondence to Aaron T. Wright.

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Fig. 1: Gut commensal organisms play an important role in the conversion of choline to disease-associated TMA.