APOBEC3 restriction, known to inhibit retroviruses by interfering with genome replication and hypermutating viral DNA, targets the γ-herpesvirus Epstein–Barr virus and is antagonized by the viral BORF2 protein.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Harris, R. S. & Dudley, J. P. Virology 479, 131–145 (2015).
Pollpeter, D. et al. Nat. Microbiol. 3, 220–233 (2018).
Cheng, A. Z. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0284-6 (2018).
Zou, J., Wang, C., Ma, X., Wang, E. & Peng, G. Cell Biosci. 7, 29 (2017).
Kidd, J. M., Newman, T. L., Tuzun, E., Kaul, R. & Eichler, E. E. PLoS Genet. 3, e63 (2007).
Middlebrooks, C. D. et al. Nat. Genet. 48, 1330–1338 (2016).
The authors declare no competing interests.
About this article
Cite this article
Malim, M.H., Pollpeter, D. APOBEC restriction goes nuclear. Nat Microbiol 4, 6–7 (2019). https://doi.org/10.1038/s41564-018-0323-3