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VIRAL INNATE IMMUNITY

APOBEC restriction goes nuclear

Nature Microbiologyvolume 4pages67 (2019) | Download Citation

APOBEC3 restriction, known to inhibit retroviruses by interfering with genome replication and hypermutating viral DNA, targets the γ-herpesvirus Epstein–Barr virus and is antagonized by the viral BORF2 protein.

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References

  1. 1.

    Harris, R. S. & Dudley, J. P. Virology 479, 131–145 (2015).

  2. 2.

    Pollpeter, D. et al. Nat. Microbiol. 3, 220–233 (2018).

  3. 3.

    Cheng, A. Z. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0284-6 (2018).

  4. 4.

    Zou, J., Wang, C., Ma, X., Wang, E. & Peng, G. Cell Biosci. 7, 29 (2017).

  5. 5.

    Kidd, J. M., Newman, T. L., Tuzun, E., Kaul, R. & Eichler, E. E. PLoS Genet. 3, e63 (2007).

  6. 6.

    Middlebrooks, C. D. et al. Nat. Genet. 48, 1330–1338 (2016).

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Author information

Affiliations

  1. Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London, London, UK

    • Michael H. Malim
    •  & Darja Pollpeter

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The authors declare no competing interests.

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Correspondence to Michael H. Malim or Darja Pollpeter.

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https://doi.org/10.1038/s41564-018-0323-3

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