VIRAL INNATE IMMUNITY

APOBEC restriction goes nuclear

APOBEC3 restriction, known to inhibit retroviruses by interfering with genome replication and hypermutating viral DNA, targets the γ-herpesvirus Epstein–Barr virus and is antagonized by the viral BORF2 protein.

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Fig. 1: Mechanisms of viral evasion from APOBEC3-mediated restriction.

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Correspondence to Michael H. Malim or Darja Pollpeter.

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Malim, M.H., Pollpeter, D. APOBEC restriction goes nuclear. Nat Microbiol 4, 6–7 (2019). https://doi.org/10.1038/s41564-018-0323-3

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