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Tagging the type VI secretion system

A powerful in vivo biotinylation approach identifies TagA as a binding partner of TssA, a central regulator of the assembly of the type VI secretion system (T6SS). TagA terminates assembly of the T6SS tail and tethers it to the membrane, acting as a crossbow latch that allows for efficient firing.

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Fig. 1: Role of TagA in terminating T6SS assembly, triggering and prey cell killing.


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Correspondence to Olivera Francetic.

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Francetic, O. Tagging the type VI secretion system. Nat Microbiol 3, 1190–1191 (2018).

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