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VIRAL IMMUNE RESPONSE

Dusting for flu’s fingerprints

A key step of the antiviral immune response is detection of the viral intruder. Infection with highly pathogenic strains of influenza virus is now shown to produce short aberrant viral RNAs that potently trigger activation of innate immunity.

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Fig. 1: Infection by high-pathogenicity IAV strains results in the production of mvRNAs that activate innate immunity via the pathogen sensor RIG-I.

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Correspondence to Michaela U. Gack.

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Riedl, W., Gack, M.U. Dusting for flu’s fingerprints. Nat Microbiol 3, 1196–1197 (2018). https://doi.org/10.1038/s41564-018-0270-z

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