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MICROBIOME

Taming the beasts within

How the immune system handles the relentless presence of commensal bacteria is an area of great interest. Here, researchers describe a role for autophagy in mediating tolerance to the microbiota, the absence of which can impart beneficial resistance to infection but also possible detriment in the form of autoimmunity.

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Fig. 1: Autophagy inhibits type I IFN response to commensal gut bacteria.

References

  1. Sampson, T. R. et al. Cell 167, 1469–1480 (2016).

    Article  CAS  Google Scholar 

  2. Martin, P. K. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0229-0 (2018).

  3. Hampe, J. et al. Nat. Genet. 39, 207–211 (2007).

    Article  CAS  Google Scholar 

  4. Cadwell, K. et al. Nature 456, 259–263 (2008).

    Article  CAS  Google Scholar 

  5. Sil, P., Muse, G. & Martinez, J. Curr. Opin. Immunol. 50, 21–31 (2018).

    Article  CAS  Google Scholar 

  6. Youle, R. J. & Narendra, D. P. Nat. Rev. Mol. Cell Biol. 12, 9–14 (2011).

    Article  CAS  Google Scholar 

  7. West, A. P., Shadel, G. S. & Ghosh, S. Nat. Rev. Immunol. 11, 389–402 (2011).

    Article  CAS  Google Scholar 

  8. Marchiando, A. M. et al. Cell Host Microbe 14, 216–224 (2013).

    Article  CAS  Google Scholar 

  9. Crow, M. K. Nat. Rev. Rheumatol. 12, 439–440 (2016).

    Article  CAS  Google Scholar 

  10. Agrawal, H. et al. J. Immunol. 183, 6021–6029 (2009).

    Article  CAS  Google Scholar 

  11. Banchereau, J. & Pascual, V. Immunity 25, 383–392 (2006).

    Article  CAS  Google Scholar 

  12. Martinez, J. et al. Nature 533, 115–119 (2016).

    Article  CAS  Google Scholar 

  13. Martinez, J. et al. Nat. Cell Biol. 17, 893–906 (2015).

    Article  CAS  Google Scholar 

  14. Postler, T. S. & Ghosh, S. Cell Metab. 26, 110–130 (2017).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Jennifer Martinez.

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Martinez, J. Taming the beasts within. Nat Microbiol 3, 1080–1081 (2018). https://doi.org/10.1038/s41564-018-0264-x

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