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BACTERIAL PHYSIOLOGY

Growth at best and worst of times

It has been assumed that bacteria adapt to nutrient limitation by adjusting the number of ribosomes, no matter what they are being starved for. Instead, two recent studies show that Escherichia coli uses different approaches depending on whether its growth is limited by the availability of carbon, nitrogen or phosphate.

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Fig. 1: The three ways to slow bacterial growth.

References

  1. Schaechter, M., Maaloe, O. & Kjeldgaard, N. O. J. Gen. Microbiol. 19, 592–606 (1958).

    CAS  Article  Google Scholar 

  2. Bremer, H. & Dennis, P. P. in Escherichia coli and Salmonella: Cellular and Molecular Biology (ed. Neidhardt, F. C) 1553–1569 (ASM Press, Washington, DC, 1996).

  3. Potrykus, K. & Cashel, M. Annu. Rev. Microbiol. 62, 35–51 (2008).

    CAS  Article  Google Scholar 

  4. Potrykus, K., Murphy, H., Philippe, N. & Cashel, M. Environ. Microbiol. 13, 563–575 (2011).

    CAS  Article  Google Scholar 

  5. Iyer, S., Le, D., Park, B. R. & Kim, M. Nat. Microbiol. 3, 741–748 (2018).

    CAS  Article  Google Scholar 

  6. Li, S. H.-J. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0199-2 (2018).

  7. McGary, K. & Nudler, E. Curr. Opin. Microbiol. 16, 112–117 (2013).

    CAS  Article  Google Scholar 

  8. Artsimovitch, I. Mol. Microbiol. 108, 467–472 (2018).

    CAS  Article  Google Scholar 

  9. Liu, C. C., Jewett, M. C., Chin, J. W. & Voigt, C. A. Nat. Chem. Biol. 14, 103–106 (2018).

    Article  Google Scholar 

Download references

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Correspondence to Michael Cashel.

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Potrykus, K., Cashel, M. Growth at best and worst of times. Nat Microbiol 3, 862–863 (2018). https://doi.org/10.1038/s41564-018-0207-6

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