Topical administration of aminoglycoside antibiotics has been shown to induce expression of interferon-stimulated genes in dendritic cells, inducing an antiviral state in the vaginal and lung mucosa that increases resistance to infection with herpes simplex virus 1, influenza and Zika viruses.
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Cohen, J.I. New activities for old antibiotics. Nat Microbiol 3, 531–532 (2018). https://doi.org/10.1038/s41564-018-0152-4